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About Us

Our research program focuses on the innovation of cutting-edge catalysis reaction and its usage as a core technology to enrich organic chemistry to address the problems in pharmaceutical synthesis and to advance industrial and material science. We focus on five major areas: 1) design and development of new ligands; 2) application in chemo-, regio-, and enantioselective cross-coupling reactions; 3) and a variety of transition metal-catalyzed coupling reactions, e.g. the activation of inert carbon-heteroatom bond; 4) DFT study on reaction mechanisms; 5) synthesis of pharmaceutically active molecules and functional materials.

Notice:

Positions for Ph.D. students, M.Phil. students, research assistants, postdoc. fellows, final year project students, and student helpers are now available! If you are interested in joining our group, please contact Dr. So by email with CV and research summary.

Group News:

[Publication] 2024-3: Our new paper "Regio- and Chemoselective Palladium-Catalyzed Additive-Free Direct C─H Functionalization of Heterocycles with Chloroaryl Triflates Using Pyrazole-Alkyl Phosphine Ligands" has been published in Adv. Sci.!

[Publication] 2024-2: Our new paper "Palladium-Catalyzed Chemoselective Amination of Chloro(hetero)aryl Triflates Enabled by Alkyl-Pyrazole-Based Phosphine Ligands" has been published in Adv. Synth. Catal.!

[Achievement] 2023-12: Congratulations to Dr. So: Asian Core Program Lectureship Awards (Malaysia & Singapore)!

[Publication] 2023-12: Our new paper "Palladium-Catalyzed Chemoselective Suzuki–Miyaura Cross-Coupling Reaction of Poly(pseudo)halogenated Arenes" has been published in J. Organomet. Chem.!

[Achievement] 2023-12: Congratulations to Shan Shan: ABCT Excellence Award 2023 (Outstanding Postgraduate Student)!

[Publication] 2023-11: Our new paper "Palladium-Catalyzed Deuterodehalogenation of Halogenated Aryl Triflates Using Isopropanol-d8 as the Deuterium Source" has been published in Org. Lett.!

[Event] 2023-9: Welcome Mr. Chuan Han to join our research group!

[Publication] 2023-6: Our new paper "Recent advances in the application of ligands in palladium-catalyzed chemoselective coupling reactions at C–Br, C–OTf, and C–Cl sites" has been published in Org. Chem. Front.!

[Publication] 2022-12: Our new paper "Palladium-Catalyzed Desulfinative Cross-Coupling of Polyhalogenated Aryl Triflates with Aryl Sulfinate Salts: Inversion of Traditional Chemoselectivity" has been published in Chin. J. Chem.!

[Achievement] 2022-11: Congratulations to Shan Shan: Poster Award in The 29th Symposium on Chemistry Postgraduate Research in Hong Kong!

[Publication] 2022-11: Our new paper "Palladium-catalyzed desymmetric hydrophosphination of 3,3-disubstituted cyclopropenes" has been published in Chem Catal.!

[Publication] 2022-3: Our new paper "Palladium-catalyzed chemoselective direct α-arylation of carbonyl compounds with chloroaryl triflates at the C–Cl site" has been published in Chem. Sci.!

[Publication] 2022-3: Our new paper "Palladium-Catalyzed Chemoselective Borylation of (Poly)halogenated Aryl Triflates and Their Application in Consecutive Reactions" has been published in Adv. Synth. Catal.!

[Publication] 2022-2: Our new paper "Palladium-Catalyzed Site-Selective Arylation of α,β-Unsaturated Carbonyl Compounds through a Ligand-Controlled Strategy" has been published in Synlett!

[Publication] 2022-1: Our new paper "An indole-amide-based phosphine ligand enabling a general palladium-catalyzed sterically hindered Suzuki–Miyaura cross-coupling reaction" has been published in Org. Biomol. Chem.!

[Publication] 2022-1: Our new paper "Inverting Conventional Chemoselectivity in the Sonogashira Coupling Reaction of Polyhalogenated Aryl Triflates with TMS-Arylalkynes" has been published in Org. Lett.!

[Publication] 2021-6: Our new paper "General Chemoselective Suzuki–Miyaura Coupling of Polyhalogenated Aryl Triflates Enabled by an Alkyl-Heteroaryl-Based Phosphine Ligand" has been published in ACS Catal.!

[Publication] 2021-3: Our new paper "Palladium-Phenylpyrazolylphosphine-Catalyzed Cross-Coupling of Alkenyl Pivalates" has been published in Asian. J. Org. Chem.!

[Publication] 2020-10: Our new paper " A Ligand Control of Palladium‐Catalyzed Site‐Selective α‐ and γ‐Arylation of α,β‐Unsaturated Ketones with (Hetero)aryl Halides" has been published in Angew. Chem. Int. Ed.!

[Publication] 2020-9: Our new paper " Application of CM-Phos Ligand in Palladium-catalyzed Cross-coupling Reactions" has been published in Chemical Journal of Chinese Universities!

[Event] 2020-9: Welcome Ms. Zifang Peng to join our research group!

[Event] 2020-7: Welcome Dr. Miao Wang to join our research group!

[Event] 2020-6: Welcome Mr. Changxue Gu to join our research group!

[Publication] 2020-5: Our new paper "Pd-Catalyzed Cross-Coupling of Highly Sterically Congested Enol Carbamates with Grignard Reagents via C–O Bond Activation" has been published in Org. Lett.!

[Publication] 2020-3: Our new paper "Palladium-catalyzed cross-coupling of (hetero)aryl or alkenyl sulfonates with aryl titanium as the multi-functional reagent" has been published in Org. Chem. Front.!

[Publication] 2020-2: Our new paper "Palladium‐Catalyzed Direct α‐Arylation of Arylacetonitriles with Aryl Tosylates and Mesylates" has been published in Eur. J. Org. Chem.!

[Event] 2019-10: Welcome Ms. Shan Shan Ng to join our research group!

[Event] 2019-9: Welcome Ms. Carmen Yu to join our research group!

[Publication] 2019-5: Our new paper "Palladium-Catalyzed C(sp2)–N Bond Cross-Coupling with Triaryl Phosphates" has been published in J. Org. Chem.!

[Publication] 2019-5: Our new paper "Exploration of Aryl Phosphates in Palladium-Catalyzed Mono-α-arylation of Aryl and Heteroaryl Ketones" has been published in J. Org. Chem.!

[Publication] 2019-3: Our new paper "Synthesis of Flavone Derivatives through Versatile Palladium-Catalyzed Cross-Coupling Reactions of Tosyloxy- and Mesyloxyflavones" has been published in Synlett.!

[Event] 2019-1: Welcome Mr. Jun Yu Wu to join our research group!

[Event] 2018-8: Welcome Mr. Zicong Chen and Xiangmeng Chen to join our research group!

[Event] 2018-6: Welcome Mr. Ernest Pang to join our research group!